People with pancreatic cancer often have no symptoms until the cancer has spread (metastasised) to other organs.
Exocrine and endocrine pancreatic cancers can have different symptoms.
The most common symptoms of exocrine pancreatic cancer are:
Endocrine pancreatic cancers that release excess hormones into the bloodstream cause different symptoms, depending on the type of hormone-producing cell involved. For example, if the cancer affects the cells that make insulin (a hormone that lowers blood glucose levels), too much insulin will be produced, leading to low blood glucose levels and symptoms such as weakness, confusion and sweating. If the cancer affects cells that produce gastrin (a hormone that tells the stomach to make acid), too much gastrin and therefore too much acid will be produced, leading to stomach problems.
Nonfunctional neuroendocrine tumours, which do not produce excess hormones, usually only cause symptoms when they become quite large. The symptoms can be similar to those of exocrine pancreatic cancer.
Endocrine pancreatic cancers often spread to the liver and affect liver function, causing jaundice, pain and loss of appetite.
Many conditions can cause these symptoms, not just pancreatic cancer. If you have any of these symptoms, talk to your doctor.
American Cancer Society (2015). Pancreatic cancer http://www.cancer.org/cancer/pancreaticcancer/detailedguide/index.
National Cancer Institute (2015). Pancreatic neuroendocrine tumors (islet cell tumors) treatment (PDQ®) http://www.cancer.gov/cancertopics/pdq/treatment/isletcell/Patient, patient version.
National Cancer Institute (2015). Pancreatic cancer treatment (PDQ®) http://www.cancer.gov/cancertopics/pdq/treatment/pancreatic/Patient, patient version.