Appendix 2: Evidence Summaries for Grading the Recommendations

Four Recommendations have been made based on the following key questions -

What is the effectiveness of hypofractionated radiotherapy compared to conventionally fractionated radiotherapy for the treatment of early breast cancer?

In patients with early breast cancer who require post-operative whole breast radiotherapy who meet the following criteria:
- aged 50 years and over
- with pathological stage T1-2, N0, M0
- who have undergone breast conserving surgery, with clear surgical margins

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What is the effectiveness of hypofractionated radiotherapy compared to conventionally fractionated radiotherapy for the treatment of early breast cancer?

For patients who do not meet the selection criteria for Recommendation 1

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What is the optimal schedule for hypofractionated radiotherapy for the treatment of early breast cancer?

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What is the safety of hypofractionated radiotherapy compared to conventionally fractionated radiotherapy for the treatment of early breast cancer?

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Appendix 2: Evidence Summaries for Grading the Recommendations